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scicosmetsoc@online.nsk.su - Анатолий Децина
⇐ ПредыдущаяСтр 3 из 3
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Второй вариант профилактики онкологических заболеваний
Далее следует представить результаты проведённых нами исследований цитотоксичности некоторых видов китайского растительного сырья с целью выявления потенциальных ингредиентов для косметических и бальнеологических препаратов, а также для профилактических и лечебных средств (против развития онкологических заболеваний, воспалительных процессов и других подобных аномальных состояний человеческого организма).
Таблица. Результаты изучения цитопатической активности некоторых видов китайского растительного сырья
| Название препарата | С,% | R2 | ТС 50 |
| Чай зеленый Ху Нань Ми Цзян | 24.8 | 0,990 | 0,0462 |
| Чай китайский зеленый | 16.0 | 0,997 | 0,0477 |
| Чай китайский зеленый (Хай Нань) | 16.4 | 0,0580 | |
| Чай китайский Черный дракон Жень Шень У Лун (Фу Цзянь) | 16.36 | 0,997 | 0,0782 |
| Чай китайский Черный дракон Тэ Гуань Инь (Юн Нань) | 16.5 | 0,0899 | |
| Чай китайский зеленый Ху Нань Ми Цзян | 12.4 | 0,998 | 0,1039 |
| Чай китайский черный дракон – Те Гуань Инь (Фу Цянь) | 16.2 | 0,998 | 0,1222 |
| Чай китайский зеленый (Хай Нань) | 8.2 | 0,998 | 0,1259 |
| Чай китайский Си Хуан Цао (Гуан Дун) | 8.3 | 0,997 | 0,1293 |
| Чай китайский Черный дракон Жень Шень У Лун (Фу Цзянь) | 8.2 | 0,991 | 0,1362 |
| Чай китайский Черный дракон Те Гуань Инь (Фу Цянь) | 8.1 | 0,997 | 0,1474 |
| Чай китайский Черный дракон Тэ Гуань Инь (Юн Нань) | 8.3 | 0,996 | 0,1662 |
| Чай китайский черный дракон Гао Шань Ча | 16.4 | 0,998 | 0,1786 |
| Чай китайский Си Хуан Цао (Гуан Дун) | 16.6 | 1,000 | 0,1867 |
| Чай китайский зеленый Ху Нань Ми Цзян | 6.2 | 0,985 | 0,1964 |
| Чай китайский красный Ци Мэнь Хун Ча (Юн Нань) | 8.3 | 0,986 | 0,2981 |
| Чай китайский Черный дракон Жень Шень У Лун (Фу Цзянь) | 4.1 | 0,3656 | |
| Чай китайский черный (Хай Нань) | 19.1 | 0,999 | 0,3731 |
| Чай китайский красный Ци Мэнь Хун Ча (Юн Нань) | 16.7 | 0,995 | 0,3856 |
| Чай китайский зеленый Ху Нань Ми Цзян | 2.48 | 0,999 | 0,3908 |
| Чай китайский горький Чан Луо (Хай Нань) | 19.1 | 1,000 | 0,4332 |
| Чай китайский Черный дракон Гао Шань Ча | 1.6 | 0,7375 | |
| Чай китайский из цветов Цянь Жи Хун (Юн нань) | 5.5 | 0,8726 | |
| Чай китайский Черный дракон Жень Шень У Лун (Фу Цзянь) | 1.64 | 0,999 | 0,9180 |
| Чай из травки Цзяо Гу Лань (Гуан Си) | 7.97 | 1,2131 | |
| Чай из травки Цзяо Гу Лань (Гуан Си) | 15.9 | 1,000 | 1,7456 |
| Чай китайский хризантема белая (Хуан Шань) | 3.5 | 2,5085 | |
| Чай из цветов хризантемы белой (Хуан Шань) | 7.1 | 0,996 | 3,3585 |
Надеюсь, что приведенная в таблице информация может оказаться полезной как для фитотерапевтов и исследователей в области создания противораковых препаратов, так и для обычных людей, так как нужно знать, что нас с вами окружает, и не уподобляться нашим предкам, которые пробовали всё на вкус – «методом проб и ошибок». Тем более, ни в коем случае нельзя полагаться на мнение торгашей и прочей «мышкующей» братии.
По сравнению с некоторыми нашими достаточно цитотоксическими растениями (например, с экстрактами почек тополя - ТС 50 = 0.0062% или Ветренницы алтайской - ТС 50 = 0.0051) можно считать, что экстракты зелёного чая обладают средней цитотоксичностью. Но в отличие от приведенных выше растений они используются во всём мире, и хорошо изучены. Это подтверждается многочисленными исследованиями, результаты которых суммированы в приведенных ниже таблицах.
Прошу извинения за английский вариант заполнения таблиц - это вынужденное цитирование первоисточников. Но разобраться легко со словарём или используя любую систему перевода в интернет.
Таблица. Онкологические заболевания
| Заболевание | Объект (доза) | эффект | ссылка |
| esophageal cancer | 1016 patients aged 30-74 years old\ green tea | a protective effect of green tea drinking on esophageal cancer | J Natl Cancer Inst. 1994 Jun 1;86(11):855-8.Gao YT, McLaughlin JK, Blot WJ, Ji BT, Dai Q, Fraumeni JF Jr. |
| cancer | 8,552 individuals over 40 years of age\ than 10 cups the 9 years | associated with later onset of cancer; green tea has a potentially preventive effect against cancer among humans | Prev Med. 1997 Nov-Dec;26(6):769-75.Imai K, Suga K, Nakachi K. |
| Cancer | 38,540 people (14,873 men, mean age 52.8 years; 23,667 women, mean age 56.8 years), of green tea using precoded answers (never, once per day, twice to four times per day, and five or more times per day). | Our findings do not provide evidence that regular green tea consumption is related to reduced cancer risks. | Cancer Causes Control. 2001 Aug;12(6):501-8.Nagano J, Kono S, Preston DL, Mabuchi K. |
| breast and prostate cancers | in humans, in animal models\ green tea extract (GTE) (100 microg/ml) and one of its polyphenolic components, epigallocatechin (EGC; 100 microM), | a regulatory role for green tea in tumor inhibition. | Chem Biol Interact. 1999 Aug 30;122(1):59-71.Kennedy DO, Matsumoto M, Kojima A, Matsui-Yuasa I. |
| Prostate cancer | in cell culture systems and in animal models \ green tea | that people who consume tea regularly have a lower risk of prostate cancer -related deaths. Second, the incidence of prostate cancer in China, a population that consumes green tea on a regular basis, is lowest in the world. | Semin Urol Oncol. 1999 May;17(2):70-6.Gupta S, Ahmad N, Mukhtar H. |
| benign prostatic hyperplasia, baldness, and acne, as well as androgen-dependent and -independent prostate cancers | Green tea extracts, (-)Epigallocatechin-3-gallate | can modulate the production and biological actions of androgens and other hormones | Hong Kong Med J. 2001 Dec;7(4):369-74Liao S. |
| prostate cancer | Green tea | the use of green tea for prostate cancer chemoprevention | Urol Clin North Am. 2002 FGupta S, Mukhtar H.eb;29(1):49-57 |
| metastatic prostate carcinoma | take 6 g of green tea per day orally in 6 divided doses. Each dose contained 100 calories and 46 mg of caffeine. | Green tea toxicity, limited antineoplastic activity | Cancer 2003;97:1442-1446. Trump DL |
| prostate cancer | in mice\ green tea | The combination of SPC and green tea synergistically inhibited final tumor weight and metastasis and significantly reduced serum concentrations of both testosterone and DHT in vivo. | J Nutr. 2003 Feb;133(2):516-21.Zhou JR, Yu L, Zhong Y, Blackburn GL. |
| prostate cancer | that oral infusion of a polyphenolic fraction isolated from green tea (GTP) at a human achievable dose (equivalent to 6 cups of green tea/d) | The cancer-chemopreventive effects of green tea. | J Nutr. 2003 Jul;133(7 Suppl):2417S-2424SAdhami VM, Ahmad N, Mukhtar H. |
| prostate cancer | 130 incident drinking tea over 40 years for than 3 cups (1 litre) daily | that green tea is protective against prostate cancer | Int J Cancer. 2004 Jan 1;108(1):130-5Jian L, Xie LP, Lee AH, Binns CW |
| breast cancer | Rate\ laboratory studies using (-)-epigallocatechin gallate (EGCG) or crude green tea extract (5 cups or < or = 4 cups per day), in a seven-year | consumption of green tea was correlated with decreased recurrence of stage I and II breast cancer. Modifying effect of green tea on the clinical characteristics of the cancer. | Jpn J Cancer Res. 1998 Mar;89(3):254-61. Nakachi K, Suemasu K, Suga K, Takeo T, Imai K, Higashi Y. |
| breast cancer | volunteers who took 15 green tea tablets per day (2.25 g green tea extracts, 337.5 mg EGCG, and 135 mg caffeine) for 6 months. (10 cups of green tea per day). | high consumption of green tea was closely associated with decreased numbers of axillary lymph node metastases among premenopausal Stage I and II breast cancer patients | Proc Soc Exp Biol Med. 1999 Apr;220(4):225-8.Fujiki H, Suganuma M, Okabe S, Sueoka E, Suga K, Imai K, Nakachi K, Kimura S. |
| breast cancer | human subjects, in mice, human lung cancer cell line PC-9 cells\ green tea with 3H-EGCG. | high daily consumption of green tea was associated with a lower recurrence rate among Stages I and II patients. | Mutat Res. 1999 Jul 16;428(1-2):339-44.Suganuma M, Okabe S, Sueoka N, Sueoka E, Matsuyama S, Imai K, Nakachi K, Fujiki H. |
| breast cancer | breast cancer cell line, MDA-MB-468\ extract of green tea GTE-TP91 | to 45% of the metaphases were observed to exhibit this behavior | Int J Oncol. 1998, Mar; 12(3):617-20.Hsu TC, Zhao Y, Wang RY, Dickerson R, Liang JC, Wang X, Wu Y. |
| breast cancer | 8000 individuals\ daily consumption of at least ten Japanese-size cups of green tea; consuming over five cups per day | cancer onset; a follow-up study of breast cancer patients conducted at our Hospital found that stages I and II breast cancer patients consuming over five cups per day experienced a lower recurrence rate and longer disease-free period than those consuming fewer than four cups per day. | J Cancer Res Clin Oncol. 1999 Nov;125(11):589-97.Fujiki H. |
| breast cancer | 133 subjects were documented to suffer recurrence of breast cancer\ green tea | regular green tea consumption may be preventive against recurrence of breast cancer in early stage cases. | Cancer Lett. 2001 Jun 26;167(2):175-82. Inoue M, Tajima K, Mizutani M, Iwata H, Iwase T, Miura S, Hirose K, Hamajima N, Tominaga S. |
| mammary tumor | in rats\ green tea | green tea had significant chemopreventive effects on carcinogen-induced mammary tumorigenesis in female S-D rats. | J Cell Biochem. 2001;82(3):387-98. Kavanagh KT, Hafer LJ, Kim DW, Mann KK, Sherr DH, Rogers AE, Sonenshein GE. |
| breast cancer | in vitro assays (human umbilical vein endothelial cells (HUVECs) and in human breast cancer cells MDA-MB231) and in animal models\ mixed green tea extract (GTE) as well as its individual catechin components (that 40 microg/ml GTE or EGCG). | Since cancer is angiogenesis dependent, this may partially explain the antineoplastic effects associated with green tea consumption. | Int J Oncol. 2002 Sep;21(3):487-91.Sartippour MR, Heber D, Zhang L, Beatty P, Elashoff D, Elashoff R, Go VL, Brooks MN |
| breast cancer | green tea extract (GTE), its individual catechin \ MDA-MB231 breast cancer cell and human umbilical vein endothelial cell (HUVEC) | antiangiogenic effects of green tea, which may contribute to its potential use for breast cancer treatment and/or prevention. | J Nutr. 2002 Aug;132(8):2307-11. Sartippour MR, Shao ZM, Heber D, Beatty P, Zhang L, Liu C, Ellis L, Liu W, Go VL, Brooks MN. |
| breast cancer | 501 breast cancer patients and 594 control subjects\ green tea | green tea drinkers showed a significantly reduced risk of breast cancer. Risk of breast cancer was not related to black tea consumption | Int J Cancer. 2003 Sep 10; 106(4):574-9.Wu AH, Yu MC, Tseng CC, Hankin J, Pike MC. |
| gastrointestinal carcinogenesis, colon carcinogenesis | Mouse, rat \ green tea extract (that 1 g per day of GTE) | GTE inhibited chemical carcinogenesis of the gastrointestinal tract in rodents. | Cancer. 1996 Apr 15;77(8 Suppl):1662-7.Yamane T, Nakatani H, Kikuoka N, Matsumoto H, Iwata Y, Kitao Y, Oya K, Takahashi T. |
| colonic carcinogenesis | Rat\ injection of 1,2-dimethylhydrazine and green tea extract (GTE) | previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. | Cancer Lett. 1996 Jul 12;104(2):205-9.Matsumoto H, Yamane T, Inagake M, Nakatani H, Iwata Y, Takahashi T, Nishimura H, Nishino H, Nakagawa K, Miyazawa T. |
| gastrointestinal cancer | in hamsters\ green tea extract (0.5 mg/L) in their drinking water/24 weeks | GTE has an inhibitory effect on the process of pancreatic carcinogenesis and on tumor promotion of transplanted pancreatic cancer. | Pancreas. 1997 Oct;15(3):272-7.Hiura A, Tsutsumi M, Satake K. |
| familial polyposis | seven patients\ treated with 5-fluorouracil suppositories and green tea extract after surgery. | Some regression of the polyps in the preserved rectal segment was observed, and no rectal cancer developed in any of these patients. | Nippon Geka Gakkai Zasshi. 1998 Jun;99(6):391-5.Ichikawa D, Takahashi T, Adachi T, Kimura A, Shirasu M, Matsumoto H, Kitamura K, Yamane T, Yamaguchi T. |
| colonic mucosa cancer | Wistar rats\ aqueous solutions of green tea extracts (GTE; 0.02%, wt/vol) plus azoxymethane (15 mg/kg i.p.) | the majority (80%) of the remaining aberrant foci contained only one or two preneoplastic crypts. | Nutr Cancer. 2000;38(1):60-4Metz N, Lobstein A, Schneider Y, Gosse F, Schleiffer R, Anton R, Raul F.. |
| colorectal tumours | F344 rats\ polyphenolic extracts from black tea, green tea or red wine | that black tea and wine extracts, but not green tea extracts, can protect against AOM-induced colon carcinogenesis. | Carcinogenesis. 2000 Nov;21(11):1965-9.Caderni G, De Filippo C, Luceri C, Salvadori M, Giannini A, Biggeri A, Remy S, Cheynier V, Dolara P. |
| gastric cancer | 419 cases of gastric cancer (in 296 men and 123 women) | Green-tea consumption was not associated with the risk of gastric cancer. | N Engl J Med. 2001 Mar 1;344(9):632-6. Tsubono Y, Nishino Y, Komatsu S, Hsieh CC, Kanemura S, Tsuji I, Nakatsuka H, Fukao A, Satoh H, Hisamichi S. |
| aberrant crypt foci | in Wistar rats\2% green tea water extract plus 1,2-dimethylhydrazine (20 mg/kg s.c.) - Week 16 | that green tea drinking inhibited ACF formation in rats, and such effects may be related to the suppression of cell proliferation in the intestinal crypts. | Nutr Cancer. 2001;39(2):239-43.Jia X, Han C. |
| intestinal tumor formation - adenocarcinoma | in Min mice\ green tea extract and sulindac | that green tea extract inhibited tumor growth in Min mice almost as potently as sulindac itself did. Combination cancer chemoprevention with green tea, looking at the goal of truly effective cancer prevention. | J Cancer Res Clin Oncol. 2001 Jan;127(1):69-72.Suganuma M, Ohkura Y, Okabe S, Fujiki H. |
| stomach cancer | Fractionation of green tea extract against human stomach cancer (MK-1) cells | guided by antiproliferative activity | Biol Pharm Bull. 2002 Sep;25(9):1238-40. Kinjo J, Nagao T, Tanaka T, Nonaka G, Okawa M, Nohara T, Okabe H. |
| stomach and prostate cancers | Human, experimental animals \green tea | anti-cancer activities of green tea and/or EGCG. | Amino Acids. 2002;22(1):1-13.Bachrach U, Wang YC. |
| stomach cancer | 30 370 men and 42 481 women aged 40-79 | We found no inverse association between green tea consumption and the risk of stomach cancer death | Br J Cancer. 2002 Jul 29;87(3):309-13. Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T |
| Gastrointestinal cancer (stomach or intestine) | Human\ green tea | a protective effect of green tea on adenomatous polyps and chronic atrophic gastritis formations | Aliment Pharmacol Ther. 2004 Mar;19(5):497-510.Borrelli F, Capasso R, Russo A, Ernst E. |
| stomach cancer | 157 incident cases and 285 controls aged 40-79 years\ drinking one or two, three or four, five to nine, and 10 or more cups of green tea per day. | We found no inverse association between green tea consumption and the risk of stomach cancer | Br J Cancer. 2004 Jan 12;90(1):135-8Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T |
| oral leukoplakia | 64 humans\Two dosages of green tea were utilized: 3.6 g per day and 5.4 g per day 6-month | .Overall compliance was excellent, with participants consuming approximately 80% of prescribed packets. | Am J Surg. 1997 Nov; 174(5):552-5. No authors listed |
| oral cancer | green tea extracts, green tea polyphenols, epigallocatechin-3-gallate (EGCG\ on normal human keratinocytes and oral carcinoma cells | Regular consumption of green tea could be beneficial in the prevention of oral cancer | Gen Dent. 2002 Mar-Apr;50(2):140-6. Hsu SD, Singh BB, Lewis JB, Borke JL, Dickinson DP, Drake L, Caughman GB, Schuster GS. |
| oral cancer | Humans\ After holding either green tea leaves (2 g) or brewed black tea (2 g of black tea leaves in 100 ml) in the mouth for 2-5 min and thoroughly rinsing the mouth, high concentrations of catechins (C(max) = 131.0-2.2 micro M) and theaflavins (C(max) = 1.8-0.6 micro M) were observed in saliva in the 1st hour. | possible use of tea in the prevention of oral cancer and dental caries. | Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):132-7.Lee MJ, Lambert JD, Prabhu S, Meng X, Lu H, Maliakal P, Ho CT, Yang CS. |
| lung carcinoma | in rat\ drinking 2% green tea extract | The mortality ratio (0.5047) was smaller in the experimental group than in the positive control group, and the survival curve of the experimental group significantly raised up, in comparison with the positive group. | Biomed Environ Sci. 1995 Mar;8(1):54-8.Luo SQ, Liu XZ, Wang CJ. |
| Lewis lung cancer | C57/BL6J mice, green tea | green tea had obvious inhibition in Lewis lung cancer and protective effects. | Zhonghua Yu Fang Yi Xue Za Zhi. 1997 Nov;31(6):325-9.Zhu M, Gong Y, Ge G. |
| tobacco smoke-induced lung tumorigenesis | strain A/J mice\ green tea extract | Green tea extract did not reduce lung tumor multiplicity in animals treated with a single dose of carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Carcinogenesis. 1998 Oct;19(10):1789-94.Witschi H, Espiritu I, Yu M, Willits NH. |
| lung cancer | human lung cancer cell line, PC-9 cells with G2/M arrest. Humans\10 cups of green tea per day was 8.7 years; | main constituent of green tea and tea polyphenols. EGCG and other tea polyphenols inhibited growth of cancer cell line. Cancer onset of patients who had consumed over 10 cups of green tea per day was 8.7 years later among females and 3.0 years later among males, compared with patients who had consumed under three cups per day. | Mutat Res. 1998 Jun 18;402(1-2):307-10.Fujiki H, Suganuma M, Okabe S, Sueoka N, Komori A, Sueoka E, Kozu T, Tada Y, Suga K, Imai K, Nakachi K. |
| lung cancer | A/J mice \green tea, administered as drinking water, inhibits lung tumor development in | that support green and black tea and caffeine as potential preventive agents against lung cancer. | Proc Soc Exp Biol Med. 1999 Apr;220(4):244-8. Chung FL. |
| lung cancer | nonsmoking women | The inconsistency in the association between drinking tea and the risk of lung cancer. | Epidemiology. 2001 Nov;12(6):695-700. Zhong L, Goldberg MS, Gao YT, Hanley JA, Parent ME, Jin F. |
| lung cancer | in human lung cancer cell line PC-9\ green tea extract | combination cancer chemoprevention with green tea, looking at the goal of truly effective cancer prevention. | J Cancer Res Clin Oncol. 2001 Jan;127(1):69-72. Suganuma M, Ohkura Y, Okabe S, Fujiki H. |
| lung cancer | 12 healthy subjects\ the green tea extract | the chemopreventive effects of green tea extract on BPDE-induced DNA damage | Cancer Detect Prev. 2002;26(6):411-8. Zhang H, Spitz MR, Tomlinson GE, Schabath MB, Minna JD, Wu X. |
| tumors of the lung, the gastrointestinal tract and the liver | Humans\ green tea | By inactivation of proteolytic enzymes they inhibit the development of metastases, the protective effects of green tea constituents. | Wien Med Wochenschr. 2002;152(5-6):153-8. Bertram B, Bartsch H. |
| hepatocarcinogenesis | Male F344 rats \black tea extract and oolong tea extract | black tea extract and oolong tea extract have a chemopreventive action against hepatocarcinogenesis. | Jpn J Cancer Res. 1996 Oct;87(10):1034-8.Matsumoto N, Kohri T, Okushio K, Hara Y. |
| liver carcinogenesis | male Fischer 344 rats\ GTE at doses of 0, 0.01 and 0.1% in the drinking water from week 2 for 10 weeks | GTE may be a possible chemopreventive agent for nitrosamine-initiated hepatocarcinogenesis in the absence of chronic hepatocyte damage, it does not significantly inhibit lesion development in hepatocarcinogenesis associated with the CDAA diet, a cirrhosis-associated model. | Jpn J Cancer Res. 1997 Apr;88(4):356-62.Tamura K, Nakae D, Horiguchi K, Akai H, Kobayashi Y, Satoh H, Tsujiuchi T, Denda A, Konishi Y. |
| skin cancer | in hairless mice\ Black tea or green tea. | Consumption of either green or black tea resulted in significantly fewer skin papillomas and tumours induced by UVA + B light, however black tea provided better protection against UVB-induced tumours than green tea. | Mutat Res. 1998 Nov 9;422(1):191-9.Record IR, Dreosti IE. |
| skin hyperplasia and hyperkeratosis | SKH-1 mice \ that oral administration of a standardized green tea extract (SGTE) and black tea extracts | demonstrated that green tea, black tea and constituent polyphenols protect against chemical- and ultraviolet B (UVB)-induced carcinogenesis and reduce the growth of established tumors in skin | J Dermatol. 2000 Nov;27(11):691-5.Bickers DR, Athar M. |
| epithelial neoplasms | Pretreatment with the topically applied green tea extract (1 mg/cm2) largely abrogated the acute Cyclooxygenase -2 response to UVB in mice or humans | assess the anti-inflammatory and anticarcinogenic effects of green tea extracts, potent anticarcinogenic effects in UVB-induced skin cancer. | Photochem Photobiol. 2002 Jul;76(1):73-80.An KP, Athar M, Tang X, Katiyar SK, Russo J, Beech J, Aszterbaum M, Kopelovich L, Epstein EH Jr, Mukhtar H, Bickers DR. |
| cancer | Human\ GTE corresponding to a daily intake of 18.6 mg catechins/d. | The overall effect of the 10-week period without dietary fruits and vegetables was a decrease in oxidative damage to DNA, blood proteins, and plasma lipids, concomitantly with marked changes in antioxidative defence. | Br J Nutr. 2002 Apr;87(4):343-55.Young JF, Dragstedt LO, Haraldsdottir J, Daneshvar B, Kal MA, Loft S, Nilsson L, Nielsen SE, Mayer B, Skibsted LH, Huynh-Ba T, Hermetter A, Sandstrom B. |
Таблица. Сердечно - сосудистые заболевания
| Заболевание | Объект (доза) | эффект | ссылка |
| cardiovascular disease | 45 volunteers\900 mL (6 cups) mineral water, green tea, or black tea/d. (4 wk) | Consumption of 900 mL (6 cups) green or black tea/d did not affect serum lipid concentrations. | Am J Clin Nutr. 1997 Nov;66(5):1125-32.van het Hof KH, de Boer HS, Wiseman SA, Lien N, Westrate JA, Tijburg LB. |
| atherosclerosis | Human\black tea extract | that black tea inhibited the proliferation of smooth muscle cells involved in the development and progression of atherosclerosis, and suppressed the production of oxidized low-density lipoprotein, a cause of lipid accumulation. That black tea has an antiatherosclerotic action. | Biosci Biotechnol Biochem. 1998 Jan;62(1):44-8.Yokozawa T, Dong E, Nakagawa T, Kim DW, Hattori M, Nakagawa H. |
| cardiovascular disease | Human\ orally ingested green tea extract (254 mg of total catechins/subject) | The results suggested that drinking green tea contributes to prevent cardiovascular disease by increasing plasma antioxidant capacity in humans. | J Agric Food Chem. 1999 Oct;47(10):3967-73.Nakagawa K, Ninomiya M, Okubo T, Aoi N, Juneja LR, Kim M, Yamanaka K, Miyazawa T. |
| ischemia/reperfusion brain injury | Wistar rats for 3 weeks before induction of ischemia\ Green tea extract (0.5%) (orally) | eventually result in protective effect on the ischemia/reperfusion-induced brain injury and behavior deficit. | Brain Res Bull. 2000 Dec;53(6):743-9.Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Kim DB, Yun YP, Ryu JH, Lee BM, Kim PY. |
| coronary artery disease | 66 patients with proven coronary artery disease\ consumption of 450 mL tea or900 mL tea (4 weeks) | Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events. | Circulation. 2001;104:151 Stephen J. Duffy, MB, BS, PhD; John F. Keaney Jr, MD; Monika Holbrook, MA; Noyan Gokce, MD; Peter L. Swerdloff, BA; Balz Frei, PhD; Joseph A. Vita, MD |
| cardiovascular disease | Human\black tea extract | the protective effects of tea-derived flavonoids in inflammatory diseases. | Cytokine. 2001 Mar 7;13(5):280-6. Crouvezier S, Powell B, Keir D, Yaqoob P. |
| atherosclerosis | atherosclerosis-susceptible C57BL/6J, apoprotein (apo)E-deficient mice\ green tea extract (0.8 g/L). The tea extract consisted of the following (g/100 g): EGCg, 58.4; (-)-epigallocatechin (EGC), 11.7; (-)-epicatechin (EC), 6.6; (-)-gallocatechingallate (GCg), 1.6; (-)-epicatechin gallate (ECg), 0.5; and caffeine, 0.4. The estimated actual intake of tea catechin was 1.7 mg/(d. mouse). | These results suggest that chronic ingestion of tea extract prevents the development of atherosclerosis without changing the plasma lipid level in apoE-deficient mice, probably through the potent antioxidative activity of the tea. | J Nutr. 2001 Jan;131(1):27-32.Miura Y, Chiba T, Tomita I, Koizumi H, Miura S, Umegaki K, Hara Y, Ikeda M, Tomita T. |
| coronary artery disease | 49 patients\ 450 mL of black tea or water consumed initially, followed by 900 mL of tea or water daily for 4 weeks | chronic black tea consumption does not affect ex vivo platelet aggregation in patients with coronary artery disease. | Arterioscler Thromb Vasc Biol 2001;21:1084-1089. Stephen J. Duffy; Joseph A. Vita; Monika Holbrook; Peter L. Swerdloff; John F. Keaney, Jr |
| ischemia/reperfusion brain injury | animals \two doses (0.5 or 2%) of green tea extract for 3 weeks | This study therefore suggests that green tea may be a useful agent for the prevention of cerebral ischemia damage | Brain Res. 2001 Jan 5;888(1):11-18.Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Yun YP, Lee BM, Kim PY. |
| ischemia | Rats \green tea extract (GTE). Free radicals in bile were trapped with the spin-trapping reagent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (4-POBN) and measured using electron spin resonance spectroscopy. | these results demonstrate that GTE scavenges free radicals in the liver after ischemiareoxygenation, thus preventing formation of toxic cytokines. | Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G957-64.Zhong Z, Froh M, Connor HD, Li X, Conzelmann LO, Mason RP, Lemasters JJ, Thurman RG. |
| atopic dermatitis and chronic venous insufficiency | Human\dietary supplements (tea tree oil) | The use of complementary/alternative medicine treatments is not free of risk; direct and indirect risks associated with CAM must be considered. | Am J Clin Dermatol. 2002;3(5):341-8.Ernst E, Pittler MH, Stevinson C. |
| cardiovascular disease | human \green tea extract corresponding to a daily intake of 18.6 mg catechins/d | The overall effect of the 10-week period without dietary fruits and vegetables was a decrease in oxidative damage to DNA, blood proteins, and plasma lipids, concomitantly with marked changes in antioxidative defence. | Br J Nutr. 2002 Apr;87(4):343-55.Young JF, Dragstedt LO, Haraldsdottir J, Daneshvar B, Kal MA, Loft S, Nilsson L, Nielsen SE, Mayer B, Skibsted LH, Huynh-Ba T, Hermetter A, Sandstrom B. |
| cardiovascular disease | Of the 1900 patients, 1019 consumed no tea (nondrinkers), 615 consumed <14 cups per week (moderate tea drinkers), and 266 consumed 14 or more cups per week (heavy tea drinkers). | the effects of tea consumption on mortality after acute myocardial infarction are unknown. Self-reported tea consumption in the year before acute myocardial infarction is associated with lower mortality after infarction. | Circulation 2002;105:2476-2481. Kenneth J. Mukamal, MD, MPH, MA; Malcolm Maclure, ScD; James E. Muller, MD; Jane B. Sherwood, RN; Murray A. Mittleman, MD, DrPH |
| cardiovascular disease | 4807 men and women aged  55 y.\ tea drinkers with a daily intake >375 mL
| An increased intake of tea and flavonoids may contribute to the primary prevention of ischemic heart disease. | Am. J. Clin. Nutr. 2002;75:880-886.Johanna M Geleijnse, Lenore J Launer, Deirdre AM van der Kuip, Albert Hofman and Jacqueline CM Witteman |
| cardiovascular disease | In vitro and animal, men and women\ green or black tea extract | Clinical trials employing putative intermediary indicators of disease, particularly biomarkers of oxidative stress status, suggest tea polyphenols could play a role in the pathogenesis of cancer and heart disease. | J Am Coll Nutr 2002;21:1-13.Diane L. McKay, PhD and Jeffrey B. Blumberg, PhD, FACN |
| cardiovascular disease | 13 subjects\ 1000 mL/d of green tea and black tea. 22 subjects\ 1250 mL/d of black tea (4 wk) | not altered after regular ingestion of green tea (273 ± 48 pmol/mmol creatinine) or black tea (274 ± 39 pmol/mmol creatinine) in comparison with hot water (263 ± 47 pmol/mmol creatinine; Study 1), or by regular ingestion of black tea (334 ± 71 pmol/mmol creatinine) in comparison with hot water (355 ± 75 pmol/mmol creatinine; Study 2). These results do not support the suggestion that polyphenolic antioxidants derived from tea inhibit in vivo lipid peroxidation. | J. Nutr. 2002;132:55-58.Jonathan M. Hodgson2, Kevin D. Croft, Trevor A. Mori, Valerie Burke, Lawrence J. Beilin and Ian B. Puddey |
| coronary heart disease | 7 men and 8 women, consuming a controlled diet for 3 wk/treatment\ black tea consumption | Tea consumption did not affect antioxidant status in this study. | J. Nutr. 2003, 133:3298S-3302S,Michael J. Davies*, Joseph T. Judd*,2, David J. Baer*, Beverly A. Clevidence*, David R. Paul*, Alison J. Edwards*, Sheila A. Wiseman  , Richard A. Muesing** and Shirley C. Chen 
|
| Cerebral ischemia | in rodents, such as Mongolian gerbils and stroke-prone spontaneously hypertensive rats (SHRSP)\, green tea extract | These results are important in light of an attenuation of the deleterious consequences of oxidative stress in ischemia and recirculation injury. | Toxicology. 2003 Jul 15;189(1-2):55-61.Ikeda K, Negishi H, Yamori Y. |
| decreased cardiovascular | 240 men and women 18 years or older\ a daily capsule containing theaflavin-enriched green tea extract (375 mg) (12 weeks). | The theaflavin-enriched green tea extract we studied is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated. | Arch Intern Med. 2003;163:1448-1453. David J. Maron, MD; Guo Ping Lu, MD; Nai Sheng Cai, MD; Zong Gui Wu, MD; Yue Hua Li, MD; Hui Chen, MD; Jian Qiu Zhu, MD; Xue Juan Jin, MS; Bert C. Wouters, MA; Jian Zhao, PhD |
| cardiac hypertrophy, chronic renal failure | Male Sprague-Dawley rats\ given green tea extract (0.1% and 0.25%) | Administration of green tea extract at 0.25% resulted in attenuation of left ventricular hypertrophy, hypertension, and preserved cardiac Na-K-ATPase activity in rats subjected to remnant kidney surgery (all P < 0.01). Green tea extract appears to block the development of cardiac hypertrophy in experimental renal failure. | Kidney Int. 2003 May;63(5):1785-90.Priyadarshi S, Valentine B, Han C, Fedorova OV, Bagrov AY, Liu J, Periyasamy SM, Kennedy D, Malhotra D, Xie Z, Shapiro JI. |
| cardiovascular disease | 17 228 subjects (mean age, 59.5 years)\ of tea consumption (drinking <1, 1, 2, 3, and 4 cups/day)
| Tea intake, likely consumed as black tea, was not strongly associated with a reduced risk of CVD in this population | Int. J. Epidemiol. 2003;32:527-533. Howard D Sesso1,2, Ralph S Paffenbarger, Jr1,3, Yuko Oguma1 and I-Min Lee1,2 |
Таблица. Антимикробная активность экстрактов чая
| Заболевание | Объект (доза) | эффект | Ссылка |
| influenza virus | mice \ inoculated i.n. with the mixture of influenza viruses and 2% (w/w) black tea extract | inhibits almost completely the infectivity of influenza virus to mice and that in vivo reversion of the tea-inactivated influenza virus does not occur. | Kansenshogaku Zasshi. 1994 Jul;68(7):824-9.Nakayama M, Toda M, Okubo S, Hara Y, Shimamura T. |
| diabetes | in rats \the hot water extract of black tea | The study reveals that, like green tea, black tea also possesses antidiabetic activity. | J Ethnopharmacol. 1995 Mar;45(3):223-6.Gomes A, Vedasiromoni JR, Das M, Sharma RM, Ganguly DK. |
| pathogenic bacteria, including methicillin-resistant Staphylococcus aureus | Aqueous extracts of teas in vitro | Tea extracts were bactericidal to staphylococci and Yersinia enterocolitica at well below 'cup of tea' concentrations. | FEMS Microbiol Lett. 1997 Jul 1;152(1):169-74.Yam TS, Shah S, Hamilton-Miller JM. |
| influenza infection | Humans\0.5 w/v% black tea extract twice daily (at 8 a.m. and 5 p.m.) a five month period | These results indicate that black tea extract is effective as a prophylactic agent against influenza infection. | Kansenshogaku Zasshi. 1997 Jun;71(6):487-94.Iwata M, Toda M, Nakayama M, Tsujiyama H, Endo W, Takahashi O, Hara Y, Shimamura T. |
| hepatitis | animal experiments\ oral administration of 2% green tea extrac a drinking water 1 or 2 weeks | In the study of rats, green tea effectively inhibited the hepatotoxicity induced by a single intraperitoneal injection | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1998;(116):82-91.Hasegawa R, Takekida K, Sai K, Umemura T, Tanimura A, Inoue T, Kurokawa Y. |
| methicillin-resistant Staphylococcus aureus (MRSA) and penicillin resistance in beta-lactamase-producing S. aureus. | extract of green tea in vitro \ one of which contained a virtually pure compound that showed the above-mentioned activities, at concentrations above about 2 mg/L. | reported direct antibacterial activity of tea extracts. | J Antimicrob Chemother. 1998 Aug;42(2):211-6.Yam TS, Hamilton-Miller JM, Shah S. |
| dental caries. | Extracts of green tea in vitro | Extracts of green tea strongly inhibited Escherichia coli, Streptococcus salivarius and Streptococcus mutans. The antibacterial effect of green and black tea extracts were compared with those of amoxicillin, cephradine and eugenol. | Arch Pharm Res, June 1, 1998; 21(3): 348-52. A Rasheed and M Haider |
| arthritis | Mice\ of oral consumption of GTP | Taken together our studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis. | Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4524-9.Haqqi TM, Anthony DD, Gupta S, Ahmad N, Lee MS, Kumar GK, Mukhtar H. |
| rheumatoid arthritis and Sjogren's syndrome | A 61-year-old woman\ drinking 2 to 3 liters of oolong tea per day | This case suggested that great quantities of oolong tea, one of the so-called "healthy" drinks, result in serious symptoms for patients with hypoalbuminemia. | Intern Med. 1999 Mar;38(3):252-6.Aizaki T, Osaka M, Hara H, Kurokawa S, Matsuyama K, Aoyama N, Soma K, Ohwada T, Izumi T. |
| Salmonella typhi and Salmonella paratyphi A. | Alcoholic extract of black tea in vitro | While all strains of S. paratyphi A tested were found sensitive, only 42.19% of S. typhi strains were inhibited by this extract. | Indian J Med Sci. 2001 Jul;55(7):376-81.Ciraj AM, Sulaim J, Mamatha B, Gopalkrishna BK, Shivananda PG. |
| Staphylococcus spp., seven strains of Streptococcus spp., one strain of Corynebacterium suis, 19 strains of Escherichia coli, and 26 strains of Salmonella spp. | animals \Green tea extracts | the inhibition of bacteria growth. These results indicate that GTE could be applied as a safe and useful feed material. | Livest. Prod. Sci.., March 1, 2001; 68(2-3): 217-229. N Ishihara, D -C. Chu, S Akachi, and L R. Juneja |
| influenza A and B viruses | Madin-Darby canine kidney cells \green-tea extract | and thereby inhibits the growth of influenza A and B viruses in Madin-Darby canine kidney cells. | Microbiol Immunol. 2002;46(7):491-4.Imanishi N, Tuji Y, Katada Y, Maruhashi M, Konosu S, Mantani N, Terasawa K, Ochiai H. |
| Helicobacter pylori | extract of green tea in vitro | treatments for Helicobacter pylori infections reported no significant effect. | J Antimicrob Chemother. 2003 Feb;51(2):241-6.Martin KW, Ernst E. |
| DIABETES | Male mice (2 months old) fed 10% fat diets with Western (W), Vegetarian (V), and Japanese (J) fat compositions with or without 0.03% GTE for 7 months | These findings show the possibility that Japanese eating habits combined with drinking green tea might be a factor in preventing the onset of non-insulin-dependent diabetes mellitus | Ann Nutr Metab. 2004;48(2):95-102. Epub 2004 Feb 25.Shirai N, Suzuki H. |
| oral streptococci, including Streptococcus mutans and Streptococcus sobrinus | oolong tea extract\ was added to S. mutans cells in chemically defined medium but not in complex broth media | the antibacterial activity of oolong tea extract is caused by a synergistic effect of monomeric polyphenols, which can easily bind to proteins. | Caries Res. 2004 Jan-Feb;38(1):2-8.Sasaki H, Matsumoto M, Tanaka T, Maeda M, Nakai M, Hamada S, Ooshima T. |
Приведенные данные свидетельствуют о том, что экстракты зелёного чая обладают способностью блокировать неконтролируемое деление клеток в человеческом организме и у животных (противораковая активност) и положительно влиять на сердечно - сосудистую систему..Наряду с этим его экстракты способны достаточно мягко тормозить развитие бактериальной микрофлоры и существенно снижать концентрацию различных вирусных объектов. Эти обстоятельства подтверждены в наших экспериментах на модельных бактериальных и вирусных культурах. Поэтому нам просто грешно пренебрегать зелёным чаем даже, если он горький на вкус и кому-то может не нравиться запах этого чая. Ведь именно этот пищевой продукт при постоянном применении может служить в качестве профилактического и даже лечебного средства от заболеваний, ответственных за наш ранний уход из жизни.
Вот и автор этого профилактического эссе утром выпил две чашки крепкого чая (две чайные ложечки сухого зелёного чая «с горкой» на две чашки кипятка) и в обед (добавив дополнительно ещё одну ложечку сухой заварки и 2-3 чашки кипятка) повторит эту процедуру. Так продолжается уже несколько лет, и я не собираюсь останавливаться - мне это нравится. Надеюсь, что читатели не принимают меня за торговца или рекламиста, выполняющего заказ.
А вам, уважаемые читатели, особенно в моём возрасте после всего прочитанного, неужели по утрам только кофе? Пишите - будем вместе радоваться жизни. Каждый по своему!
Анатолий Децина
(scicosmetsoc@online.nsk.su)
Date: 2015-07-02; view: 380; Нарушение авторских прав